If you’re finding yourself wondering why you entered a room, where your car keys are, or what you needed from the store more often than ever before, you may be tempted to chalk it up to a normal part of aging.
Alternatively, you might worry that this is a sign of early cognitive decline.
Rest assured, it’s a normal part of aging — but there are some things that you can do to be proactive and to keep your mind in tip-top shape. Many of them actually revolve around improving blood flow and circulation in your brain.
In this article, we’ll review:
- How aging affects blood flow and the role of blood flow in brain function and memory,
- How exercise may help reduce memory loss,
- The role of nitric oxide in improving brain blood flow,
- And how Juvenon’s BloodFlow-7 supplement may help to naturally boost nitric oxide production.
Circulation, aging, and memory
Your blood is what delivers oxygen to your tissues, as well as a delivery method for nutrients, hormones, enzymes, and more. Good circulation ensures that your blood is able to deliver oxygen and other vital materials to every corner of your body — including your brain.
Unfortunately, aging does tend to naturally impede blood flow over time, and unfortunately it can be further impeded by high blood pressure, atherosclerosis (plaque buildup within arteries), and heart problems.
This diminished blood flow can affect how much oxygen is getting to your brain, which unfortunately may also lead to memory loss or forgetfulness.
Exercise and blood flow
Exercise is one important factor that can preserve or even help improve blood flow. According to the Physical Activity Guidelines for Americans, everyone — regardless of age — should strive for 150-300 minutes of moderate physical activity each week. In addition, it’s also important to include at least 2 resistance training sessions.
Additionally, several studies have found that exercise can improve memory and brain function — particularly in older adults. Researchers even theorize that gardening may offer similar effects.[3, 4, 5]
These studies highlight the importance of engaging in regular physical activity, even if it’s not traditional “exercise” (like gardening). It’s important to find a way to move your body that you enjoy, not just for the physical benefits but also for the mental benefits.
The role of nitric oxide in memory
Another important factor to consider when it comes to blood flow and memory is nitric oxide. Nitric oxide is a gas produced by your cells that promotes vasodilation, or a relaxing of the blood vessels that allows for increased blood flow.
Nitric oxide also plays a role in memory. One way is that it helps promote blood flow in and to the brain, which is necessary for proper brain functioning.
Animal research has shown that exercise may potentially improve memory through increasing circulating nitric oxide levels, which increase blood flow.
Nitric oxide is also a neurotransmitter, or a chemical messenger for the brain and central nervous system, that plays a key role in memory formation.
This evidence suggests that increasing nitric oxide levels in the body may help to improve memory.
One convenient way to help support your body’s natural nitric oxide production is by taking Juvenon’s BloodFlow-7, a supplement made with potent natural ingredients that may help your body create more nitric oxide, use nitric oxide more effectively, or preserve its existing nitric oxide.
Here’s a bit more about each of the ingredients in BloodFlow-7, and how each may help promote or protect your nitric oxide.
Nitric Oxide Precursor Blend
BloodFlow-7’s Nitric Oxide Precursor Blend consists of three powerful compounds that your body can use to create more nitric oxide. Research has also shown that all three of these compounds may play a role in memory and brain function, as well.
Here’s what you’ll find in the Nitric Oxide Precursor Blend.
Citrulline is an amino acid, one of the compounds your body uses to make new proteins. It plays a key role in nitric oxide synthesis, because it can be converted into the amino acid arginine in your body, which is a precursor for nitric oxide.
Animal studies have shown that supplementing with citrulline does indeed help to reverse arginine deficiency and boost nitric oxide production, and one even showed that citrulline supplementation helped to improve “memory deficits.”[9, 10]
Unlike citrulline, arginine’s precursor, arginine is directly involved in nitric oxide synthesis. An enzyme called nitric oxide synthase acts directly on arginine to oxidize it (or break it down) into nitric oxide and citrulline.
Animal research has noted the benefits of arginine for memory, and a human study has noted that arginine levels in the brain appear to be lower in people with cognitive deficits or other brain-related health issues. This suggests that arginine supplementation may offer a potential solution or partial solution.[11, 12]
Research also shows that low levels of arginine may inhibit nitric oxide production, and that arginine supplementation may help promote higher levels of nitric oxide.[13, 14]
Glutathione is a potent antioxidant. As such, it protects the cells from oxidation (damage) caused by free radicals) — hence the name antioxidant.
However, glutathione also plays a key role in nitric oxide production. It is a precursor to nitric oxide synthase, the enzyme that the body utilizes to break down arginine into nitric oxide and citrulline.
For this reason, the inclusion of glutathione in BloodFlow-7 offers a two-pronged benefit:
- First, it protects the cells and your existing nitric oxide from being broken down by free radicals, and
- It promotes increased nitric oxide production by potentially helping to increase levels of nitric oxide synthase in the body.
Additionally, some evidence suggests that low glutathione levels may be linked to memory loss — as researchers have noted that animals with brain or memory impairments have lower levels of glutathione because their bodies create more of the hormone glutathione reductase, which breaks down glutathione.
Beet root extract
In addition, BloodFlow-7 also contains beet root extract. Yes, from the purple-hued, love-it-or-hate-it vegetable! Fortunately for you if you don’t like the taste of beets, BloodFlow-7 provides all of the benefits of beets in easy-to-take, tasteless capsules.
Beets are a natural source of nitrogen-based compounds called nitrites. These nitrites can be utilized by the body to create nitric oxide, which is also nitrogen-based.
Beet root extract is a popular supplement for athletes thanks to its effects on nitric oxide, which allow for increased blood flow and oxygen delivery to the tissues — improving athletic performance.
As a rich source of nitrites, beet root may help to increase nitric oxide levels through a biochemical pathway called the nitrite-nitrite-nitric oxide pathway — which includes a number of reactions that converted dietary nitrites (nitrites that you eat or consume through supplements) into nitric oxide that your body can use.
Additionally, some animal studies have linked beet root extract to improved memory. This is thought to be due to the antioxidant effects of certain compounds in beet root. Therefore, beet may have a dual purpose related to memory and blood flow — both increasing nitric oxide levels and protecting neural (brain) cells from oxidative damage.[18, 19]
Found in dark chocolate and red wine, this antioxidant helps protect NO from breakdown by free radicals. It also provides protective effects to brain cells, and may help to prevent or reverse memory loss — according to several studies.[20, 21, 22]
However, trans-resveratrol may also directly help to increase nitric oxide levels. It helps to increase levels of and activate nitric oxide synthase (the enzyme that breaks down arginine into nitric oxide), as well as prevent nitric oxide synthase from being broken down. This allows for higher circulating levels of nitric oxide synthase, which may increase circulating nitric oxide levels as well.
The S7 Blend is a potent blend of seven whole-food sources of plant-based antioxidants. It is included in BloodFlow-7 to help protect against oxidative damage caused by free radicals, which may inhibit nitric oxide.
The S7 Blend includes:
Green coffee bean extract: Green coffee contains polyphenols (plant chemicals) that may help NO to be more effective, and according to some early animal research the extract may also help to alleviate cognitive
Green tea leaf extract: Green tea may offer some benefits for memory and focus, likely due to the combination of polyphenols it contains. 
- Turmeric root extract: Turmeric contains the powerful antioxidant compound curcumin, which some studies show may help to protect against memory loss or cognitive decline.
Tart cherry: Tart cherry is often taken as a supplement on its own to help improve circulation, and one small study in older adults showed that daily supplementation with tart cherry improved memory, attention, and learning.
Blueberry: Blueberries are rich in anthocyanin antioxidants, and a handful of studies have shown that regular blueberry consumption may improve short and long term memory, as well as spatial memory.
- Broccoli: Broccoli is rich in antioxidants like quercetin and sulforaphane, which may offer protective effects in the brain.[30, 31, 32]
- Kale: Kale is a close relative of broccoli, and may provide similar effects thanks to the antioxidants it contains.
Blood flow may be key for helping to retain a sharp memory well into your senior years, and there are some key strategies that you can use to help promote healthy blood flow. The first is to exercise regularly, which is associated with increased nitric oxide production and memory improvements — along with overall better health.
The next is to make BloodFlow-7 a part of your daily routine. Its powerful ingredients can help your body to make more nitric oxide and use it more efficiently, which can provide numerous physical and mental benefits.
- Nagata K, Yamazaki T, Takano D, et al. Cerebral circulation in aging. Ageing Res Rev. 2016;30:49-60. doi:10.1016/j.arr.2016.06.001
- U.S. Department of Health and Human Services. Physical Activity Guidelines for Americans, 2nd edition. U.S. Department of Health and Human Services. 2018. Accessed April 15, 2022. https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf
- Duzel E, van Praag H, Sendtner M. Can physical exercise in old age improve memory and hippocampal function?. Brain. 2016;139(Pt 3):662-673. doi:10.1093/brain/awv407
- Makizako H, Tsutsumimoto K, Doi T, et al. Effects of exercise and horticultural intervention on the brain and mental health in older adults with depressive symptoms and memory problems: study protocol for a randomized controlled trial [UMIN000018547]. Trials. 2015;16:499. Published 2015 Nov 4. doi:10.1186/s13063-015-1032-3
- Smith PJ, Blumenthal JA, Hoffman BM, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72(3):239-252. doi:10.1097/PSY.0b013e3181d14633
- Garcia X, Stein F. Nitric oxide. Semin Pediatr Infect Dis. 2006;17(2):55-57. doi:10.1053/j.spid.2006.04.002
- Qi Y, Wang S, Luo Y, et al. Exercise-induced Nitric Oxide Contributes to Spatial Memory and Hippocampal Capillaries in Rats. Int J Sports Med. 2020;41(13):951-961. doi:10.1055/a-1195-2737
- Paul V, Ekambaram P. Involvement of nitric oxide in learning & memory processes. Indian J Med Res. 2011;133(5):471-478.
- Yabuki Y, Shioda N, Yamamoto Y, et al. Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection. Brain Res. 2013;1520:157-167. doi:10.1016/j.brainres.2013.05.011
- Martínez-González K, Serrano-Cuevas L, Almeida-Gutiérrez E, Flores-Chavez S, Mejía-Aranguré JM, Garcia-delaTorre P. Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease. Nutrition. 2021;90:111248. doi:10.1016/j.nut.2021.111248
- Yildiz Akar F, Celikyurt IK, Ulak G, Mutlu O. Effects of L-arginine on 7-nitroindazole-induced reference and working memory performance of rats. Pharmacology. 2009;84(4):211-218. doi:10.1159/000235997
- Geng CH, Wang C, Yang J, et al. Arginine vasopressin improves the memory deficits in Han Chinese patients with first-episode schizophrenia. Peptides. 2017;97:8-15. doi:10.1016/j.peptides.2017.09.002
- Hallemeesch MM, Lamers WH, Deutz NE. Reduced arginine availability and nitric oxide production. Clin Nutr. 2002;21(4):273-279. doi:10.1054/clnu.2002.0571
- Viribay A, Burgos J, Fernández-Landa J, Seco-Calvo J, Mielgo-Ayuso J. Effects of Arginine Supplementation on Athletic Performance Based on Energy Metabolism: A Systematic Review and Meta-Analysis. Nutrients. 2020;12(5):1300. Published 2020 May 2. doi:10.3390/nu12051300
- Harbrecht BG, Di Silvio M, Chough V, Kim YM, Simmons RL, Billiar TR. Glutathione regulates nitric oxide synthase in cultured hepatocytes. Ann Surg. 1997;225(1):76-87. doi:10.1097/00000658-199701000-00009
- Cruz R, Almaguer Melian W, Bergado Rosado JA. El glutatión en la función cognitiva y la neurodegeneración [Glutathione in cognitive function and neurodegeneration]. Rev Neurol. 2003;36(9):877-886.
- Lidder S, Webb AJ. Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol. 2013;75(3):677-696. doi:10.1111/j.1365-2125.2012.04420.x
- Hajihosseini S, Setorki M, Hooshmandi Z. The antioxidant activity of Beta vulgaris leaf extract in improving scopolamine-induced spatial memory disorders in rats. Avicenna J Phytomed. 2017;7(5):417-425.
- Olasehinde TA, Oyeleye SI, Ibeji CU, Oboh G. Beetroot supplemented diet exhibit anti-amnesic effect via modulation of cholinesterases, purinergic enzymes, monoamine oxidase and attenuation of redox imbalance in the brain of scopolamine treated male rats [published online ahead of print, 2020 Oct 15]. Nutr Neurosci. 2020;1-15. doi:10.1080/1028415X.2020.1831260
- Moussa C, Hebron M, Huang X, et al. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017;14(1):1. Published 2017 Jan 3. doi:10.1186/s12974-016-0779-0
- Zeng Q, Xiong Q, Zhou M, et al. Resveratrol attenuates methamphetamine-induced memory impairment via inhibition of oxidative stress and apoptosis in mice. J Food Biochem. 2021;45(2):e13622. doi:10.1111/jfbc.13622
- Zhang Y, Li Y, Wang Y, et al. Effects of resveratrol on learning and memory in rats with vascular dementia. Mol Med Rep. 2019;20(5):4587-4593. doi:10.3892/mmr.2019.10723
- Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and Vascular Function. Int J Mol Sci. 2019;20(9):2155. Published 2019 Apr 30. doi:10.3390/ijms20092155
- Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res. 2004;27(10):731-737. doi:10.1291/hypres.27.731
- Mohamed HE, Asker ME, Shaheen MA, Eissa RG, Younis NN. Alleviation of fructose-induced Alzheimer's disease in rats by pioglitazone and decaffeinated green coffee bean extract. J Food Biochem. 2021;45(5):e13715. doi:10.1111/jfbc.13715
- Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S. Green tea effects on cognition, mood and human brain function: A systematic review. Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008
- Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021;7(4):575-620. Published 2021 Aug 4.
- Chai SC, Jerusik J, Davis K, Wright RS, Zhang Z. Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial. Food Funct. 2019;10(7):4423-4431. doi:10.1039/c9fo00913b
- Travica N, D'Cunha NM, Naumovski N, et al. The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials. Brain Behav Immun. 2020;85:96-105. doi:10.1016/j.bbi.2019.04.001
- Anand David AV, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016;10(20):84-89. doi:10.4103/0973-7847.194044
- Greaney AJ, Maier NK, Leppla SH, Moayeri M. Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism. J Leukoc Biol. 2016;99(1):189-199. doi:10.1189/jlb.3A0415-155RR
- Park HS, Hwang ES, Choi GY, et al. Sulforaphane enhances long-term potentiation and ameliorate scopolamine-induced memory impairment. Physiol Behav. 2021;238:113467. doi:10.1016/j.physbeh.2021.113467