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Scientific Articles
The following peer-reviewed articles discuss multiple aspects of microbiology and pre-clinical experimentation related to aging. At least one author of each article is a member of Juvenon's Scientific Advisory Board. The articles are listed here to summarize the depth and breadth of scientific inquiry that stands behind Juvenon, Inc.
The articles are not intended to promote any specific ingredient, regimen, or use and should not be construed as evidence of the safety, effectiveness, or intended uses of the Juvenon product. The label should be consulted for intended uses and appropriate directions for use of the Juvenon product.
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Age-Associated Memory Impairment Study |
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Increasing
longevity by tuning up metabolism |
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Mineral
and vitamin deficiencies can accelerate the mitochondrial
decay of aging. |
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Delaying
the mitochondrial decay of aging with acetylcarnitine. |
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Mitochondrial
decay, a major cause of aging, can be delayed. |
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Feeding
acetyl-L-carnitine and lipoic acid to old rats significantly
improves metabolic function while decreasing oxidative stress. |
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Age-associated
mitochondrial oxidative decay: Improvement of carnitine acetyltransferase
substrate-binding affinity and activity in brain by feeding
old rats acetly-l-carnitine and/or R-alpha-lipoic acid. |
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Memory
loss in old rats is associated with brain mitochondrial decay
and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine
and/or R-alpha-lipoic acid. |
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Acetyl L-carnitine
fed to old rats partially restores mitochondrial function and
ambulatory activity. |
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Oxidative
damage and mitochondrial decay in aging. |
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The
Free Radical Theory of Aging Matures. |
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Comparison
of the effects of L-carnitine and acetyl-L-carnitine on carnitine
levels, ambulatory activity, and oxidative stress biomarkers
in the brain of old rats. |
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R-alpha-Lipoic
acid-supplemented old rats have improved mitochondrial function,
decreased oxidative damage and increased metabolic rate. |
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Age-associated
decline in ascorbic acid concentration, recycling, and biosynthesis
in rat hepatocytes - reversal with (R)-a lipoic acid supplementation. |
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R-alpha-Lipoic acid-supplemented old rats
have improved mitochondrial function, decreased oxidative damage,
and increased metabolic rate. |
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Mitochondrial
decay in hepatocytes from old rats: Membrane potential declines,
heterogeneity and oxidants increase. |
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R-alpha
lipoic acid reverses the age-related loss in redox status in
post-mitotic tissues: evidence for increased cysteine requirement
for GSH status. |
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Decline
in transcriptional activity of Nrf2 causes age-related loss
of glutathione synthesis, which is reversible with lipoic acid. |
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Meta-analysis of double blind randomized controlled clinical
trials of acetyl-L-carnitine versus placebo in the treatment of
mild cognitive impairment and mild Alzheimer's disease |
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Effectiveness of Nutritional Supplements on
Cognitive Functioning in Elderly Persons:
A Systematic Review |
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Memory loss in old rats is associated with brain
mitochondrial decay and RNA DNA oxidation:
Partial reversal by feeding acetyl-L-carnitine
and or R lipoic acid |
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L-Carnitine treatment reduces severity of physical and mental fatigue
and increases cognitive functions in centenarians: a randomized and
controlled clinical trial |
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