| Resveratrol Longevity Supplement Research and Information Sources. Resveratrol is a naturally occurring compound produced by and isolated from a variety of plants. Highly concentrated in and commonly extracted from the root of the Japanese knotweed (polygonum cuspidatum). Resveratrol is also available from red-grape skins, cranberries and peanuts. Possibility of more potent synthetic forms. Active Form. Resveratrol is commonly present in two forms: trans and cis. Virtually all the cell culture and animal studies have demonstrated that trans-resveratrol produces the positive effects, while the cis form is relatively inactive. Potential Benefits of Resveratrol. In studies with yeast cells, fruit flies and rodents, mimics the life-extending effects of caloric restriction, including improving blood pressure, cholesterol level and cardiovascular health, as well as decreasing inflammation. Believed to help breakdown fat for energy, promote normal blood sugar and bone strength, and protect DNA. Resveratrol may also promote energy balance and disease resistance. At the cellular level, it is shown to activate the SIRT1 enzyme which encourages self-repair. Also believed to increase the number of mitochondria and improve energy production. Continuing Research. Until recently, primarily animal and cell culture studies. Virtually no negative side effects observed, even at very high doses. Several studies published, demonstrating the effects of resveratrol on animal metabolism and longevity. Fed an unhealthy diet high in fat, mice developed diabetes and heart disease, were lethargic and had shorter life spans. Fed the high-fat diet supplemented by resveratrol, mice were as healthy and lived as long as those fed a nutritious diet. A number of human clinical trials in progress with initially positive results. 
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